°Ù¼ÃÉñÖÝÐû²¼ÅÁÃ×ÅÁÀûÓÃÓÚÖÎÁÆÂѳ²°©µÄÖйúÐÂÒ©ÉÏÊÐÉêÇë»ñÊÜÀí
°Ù¼ÃÉñÖÝÖ×ÁöÃâÒßѧÊ×ϯҽѧ¹ÙêÚÓÂҽѧ²©Ê¿±íʾ£º¡°ÕâÊÇÎÒÃǾÍÅÁÃ×ÅÁÀûµÝ½»µÄÊ×ÏîÐÂÒ©ÉÏÊÐÉêÇë¡£ÎÒÃÇÕë¶ÔÅÁÃ×ÅÁÀûµÄÈ«Çò¿ª·¢ÏîÄ¿ÕýÔÚ²»¶ÏÍÆ½ø£¬ÓÃÓÚÆÀ¹ÀÆä×÷Ϊµ¥Ò©»òÊÇÓë°üÀ¨¿¹PD-1¿¹Ìå°ÙÔó°²ÔÚÄ򵀮äËûÒ©ÎïÁªºÏµÄDZÄÜ¡£ÅÁÃ×ÅÁÀû×÷Ϊһ¿î°ÐÏòÖÎÁÆÒ©ÎïÄÜΪÖйúµÄÍíÆÚÂѳ²°©»¼Õß´øÀ´ÐµÄÖÎÁÆÏ£Íû¡£ÎÒÃÇÆÚ´ýÔÚ½ÓÏÂÀ´µÄ¼¸¸öÔÂÖÐÄܹ«²¼Ö§³Ö¸ÃÏîÐÂÒ©ÉÏÊÐÉêÇëµÄÁÙ´²Êý¾Ý£¬ÒÔ¼°°üÀ¨3ÆÚÊý¾ÝÔÚÄ򵀮äËûÁÙ´²½á¹û¡£¡±
µÝ½»´ËÏîNDAÊÇ»ùÓÚÒ»ÏîÅÁÃ×ÅÁÀûÓÃÓÚÖÎÁÆÍíÆÚÂѳ²°©¡¢ÊäÂѹܰ©¡¢Ô·¢ÐÔ¸¹Ä¤°©»òÍíÆÚÈýÒõÈéÏÙ°©»¼ÕßµÄ1/2ÁÙ´²ÊÔÑ飨NCT03333915£©µÄ½á¹û¡£¸ÃÊÔÑéµÄ¹Ø¼üÐÔ2ÆÚ²¿·ÖÔÚÖйúÈë×éÁË113Àý¼ÈÍù½ÓÊܹýÖÁÉÙÁ½Ïî±ê×¼»¯ÁÆ¡¢Ð¯ÓÐBRCA1/2Í»±äµÄ¸ß¼¶±ðÉÏÆ¤ÐÔÂѳ²°©£¨°üÀ¨ÊäÂѹܰ©»òÔ·¢ÐÔ¸¹Ä¤°©£©»ò¸ß¼¶±ð×Ó¹¬ÄÚĤÉÏÆ¤Ñù°©»¼Õß¡£»¼Õß½ÓÊÜÁËÅÁÃ×ÅÁÀûÿÈÕÁ½´Î¿Ú·þÓÃÒ©¡¢Ã¿´Î60 mgµÄÖÎÁÆ¡£¸ÃÊÔÑéµÄÖ÷ÒªÖÕµãΪ»ùÓÚʵÌåÖ×ÁöÁÆÐ§ÆÀ¹À±ê×¼RECIST 1.1°æµÄ¿Í¹Û»º½âÂÊ£¨ORR£©¡£ÊÔÑé½á¹û½«ÔÚδÀ´Ò»³¡Ò½Ñ§»áÒéÉϱ»¹«²¼¡£
°Ù¼ÃÉñÖݸ߼¶¸±×ܲüæÈ«ÇòÒ©ÕþÊÂÎñ¸ºÔðÈËãÆÐ¡¾üŮʿÆÀÂÛµÀ£º¡°½ñÌì»ñÊÜÀíµÄÅÁÃ×ÅÁÀûÐÂÒ©ÉÏÊÐÉêÇë±êÖ¾×ŰټÃÉñÖݵÚÈý¿î×ÔÖ÷Ñз¢²úÆ·½øÈëÒ©ÕþÉóÅú½×¶Î¡£ÎÒÃÇÆÚ´ýÔÚ¼à¹Ü»ú¹¹ÉóÅúÅÁÃ×ÅÁÀû×÷Ϊһ¿îÐÂÒ©ÖÎÁÆÍíÆÚÂѳ²°©¡¢ÊäÂѹܰ©¼°Ô·¢ÐÔ¸¹Ä¤°©µÄ¹ý³ÌÖУ¬ÓëÆäÕ¹¿ªÃÜÇеŵͨ£¬Ò²Ï£ÍûÕâ¿îÒ©ÎïºÍ°ÙÔó°²

