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[1] Simpson E L, Bieber T, Guttman-Yassky E, et al. Two phase 3 trials of dupilumab versus placebo in atopic dermatitis[J]. New England Journal of Medicine, 2016, 375(24): 2335-2348.

[2] Silverberg J I, Yosipovitch G, Simpson E L, et al. Dupilumab treatment results in early and sustained improvements in itch in adolescents and adults with moderate-to-severe atopic dermatitis: analysis of the randomized phase 3 studies SOLO 1 & SOLO 2, AD ADOL, and CHRONOS[J]. Journal of the American Academy of Dermatology, 2020.

[3] Blauvelt, Andrew, et al. "Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial."The Lancet389.10086 (2017): 2287-2303.

[4] de Bruin Weller, M., et al. "Dupilumab with concomitant topical corticosteroid treatment in adults with atopic dermatitis with an inadequate response or intolerance to ciclosporin A or when this treatment is medically inadvisable: a placebo controlled, randomized phase III clinical trial (LIBERTY AD CAFE)."British Journal of Dermatology178.5 (2018): 1083-1101.

[5] Barbarot S, Auziere S, Gadkari A, et al. Epidemiology of atopic dermatitis in adults: results from an international survey[J]. Allergy, 2018, 73(6): 1284-1293.


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